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10.1038/sj.cdd.4401706 25 KawamotoK.YagiM.StverT.KanzakiS.RaphaelY

Key Features: 80120x longer half-life than native IGF-1 Binds weakly to IGFBPs remains active longer in the bloodstream Stimulates satellite cell activation key for muscle hypertrophy Promotes lean mass gain and fat loss simultaneously No direct suppression of testosterone or HPTA function Unrepeatable Insight : IGF-1 LR3 is not a growth hormone itselfbut it is the molecule through which GH exerts most of its anabolic effects

Longitudinal registration was processed with Inscopix software and a custom MATLAB script to track the same neurons across sessions as described 71,72 ( Quantification and statistical analysis OriginPro 2017 software (OriginLab Corporation, USA) and GraphPad Prism 8 (GraphPad Software, Inc., USA) were used for the statistical analyses and graphing

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